Role of ABCB5 P-glycoprotein in Breast Cancer Multidrug Resistance
نویسنده
چکیده
Rigol N, Frank NY, Margaryan A, Schatton T, Frank MH. Differential expression of ABCB5 multidrug resistance P-glycoprotein in human breast cancer cell lines. Proceedings of the Department of Defense Breast Cancer Research Program Meeting (Era of Hope), June 8-11, 2005, Philadelphia, PA. 2005:467 Abstract P667.
منابع مشابه
Effects of Salinispora derived metabolites against multidrug resistance, an in-silico study
Background: Multidrug resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression/overactivation of ABC transporters, especially P-glycoprotein (P-gp), in the development of chemotherapy has long been demonstrated. Salinispora is a marine actinomycete genus known for the production of novel bioactive metabolites. Methods: In this...
متن کاملActivity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking
Apigenin is a common dietary flavonoid with considerable cytotoxic activity in vitro and in vivo. Despite many mechanistic studies, less is known about resistance factors hampering apigenin's activity. We investigated the ATP-binding cassette (ABC) transporters BCRP/ABCG2, P-glycoprotein/ABCB1 and its close relative ABCB5. Multidrug-resistant cells overexpressing these ABC transporters were not...
متن کاملMolecular mechanisms involved in multidrug resistance in breast cancer therapy
Breast cancer is the most prevalent cancer in women. Chemotherapy is the main strategy in the treatment of this disease especially in the advanced form of the disease. Despite the recent progress in the development of new chemotherapy, the effectiveness of these drugs has dramatically reduced due to multidrug resistance. The phenotype of multidrug resistance (MDR) can occur through different me...
متن کاملABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
Enhanced drug efflux mediated by ABCB1 P-glycoprotein and related ATP-binding cassette transporters is one of several mechanisms of multidrug resistance thought to impair chemotherapeutic success in human cancers. In malignant melanoma, its potential contribution to chemoresistance is uncertain. Here, we show that ABCB5, which functions as a determinant of membrane potential and regulator of ce...
متن کاملMolecular Determinants of Sensitivity or Resistance of Cancer Cells Toward Sanguinarine
For decades, natural products represented a significant source of diverse and unique bioactive lead compounds in drug discovery field. In Clinical oncology, complete tumors remission is hampered by the development of drug-resistance. Therefore, development of cytotoxic agents that may overcome drug resistance is urgently needed. Here, the natural benzophenanthridine alkaloid sanguinarine has be...
متن کامل